/** * A simple set of functions to check our version 1.0 update service. * * @package WordPress * @since 2.3.0 */ /** * Check WordPress version against the newest version. * * The WordPress version, PHP version, and Locale is sent. Checks against the * WordPress server at api.wordpress.org server. Will only check if WordPress * isn't installing. * * @since 2.3.0 * @uses $wp_version Used to check against the newest WordPress version. * * @param array $extra_stats Extra statistics to report to the WordPress.org API. * @param bool $force_check Whether to bypass the transient cache and force a fresh update check. Defaults to false, true if $extra_stats is set. * @return mixed Returns null if update is unsupported. Returns false if check is too soon. */ function wp_version_check( $extra_stats = array(), $force_check = false ) { if ( defined('WP_INSTALLING') ) return; global $wpdb, $wp_local_package; include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version $php_version = phpversion(); $current = get_site_transient( 'update_core' ); $translations = wp_get_installed_translations( 'core' ); // Invalidate the transient when $wp_version changes if ( is_object( $current ) && $wp_version != $current->version_checked ) $current = false; if ( ! is_object($current) ) { $current = new stdClass; $current->updates = array(); $current->version_checked = $wp_version; } if ( ! empty( $extra_stats ) ) $force_check = true; // Wait 60 seconds between multiple version check requests $timeout = 60; $time_not_changed = isset( $current->last_checked ) && $timeout > ( time() - $current->last_checked ); if ( ! $force_check && $time_not_changed ) return false; $locale = get_locale(); /** * Filter the locale requested for WordPress core translations. * * @since 2.8.0 * * @param string $locale Current locale. */ $locale = apply_filters( 'core_version_check_locale', $locale ); // Update last_checked for current to prevent multiple blocking requests if request hangs $current->last_checked = time(); set_site_transient( 'update_core', $current ); if ( method_exists( $wpdb, 'db_version' ) ) $mysql_version = preg_replace('/[^0-9.].*/', '', $wpdb->db_version()); else $mysql_version = 'N/A'; if ( is_multisite() ) { $user_count = get_user_count(); $num_blogs = get_blog_count(); $wp_install = network_site_url(); $multisite_enabled = 1; } else { $user_count = count_users(); $user_count = $user_count['total_users']; $multisite_enabled = 0; $num_blogs = 1; $wp_install = home_url( '/' ); } $query = array( 'version' => $wp_version, 'php' => $php_version, 'locale' => $locale, 'mysql' => $mysql_version, 'local_package' => isset( $wp_local_package ) ? $wp_local_package : '', 'blogs' => $num_blogs, 'users' => $user_count, 'multisite_enabled' => $multisite_enabled, ); $post_body = array( 'translations' => json_encode( $translations ), ); if ( is_array( $extra_stats ) ) $post_body = array_merge( $post_body, $extra_stats ); $url = $http_url = 'http://api.wordpress.org/core/version-check/1.7/?' . http_build_query( $query, null, '&' ); if ( $ssl = wp_http_supports( array( 'ssl' ) ) ) $url = set_url_scheme( $url, 'https' ); $options = array( 'timeout' => ( ( defined('DOING_CRON') && DOING_CRON ) ? 30 : 3 ), 'user-agent' => 'WordPress/' . $wp_version . '; ' . home_url( '/' ), 'headers' => array( 'wp_install' => $wp_install, 'wp_blog' => home_url( '/' ) ), 'body' => $post_body, ); $response = wp_remote_post( $url, $options ); if ( $ssl && is_wp_error( $response ) ) { trigger_error( __( 'An unexpected error occurred. Something may be wrong with WordPress.org or this server’s configuration. If you continue to have problems, please try the support forums.' ) . ' ' . __( '(WordPress could not establish a secure connection to WordPress.org. Please contact your server administrator.)' ), headers_sent() || WP_DEBUG ? E_USER_WARNING : E_USER_NOTICE ); $response = wp_remote_post( $http_url, $options ); } if ( is_wp_error( $response ) || 200 != wp_remote_retrieve_response_code( $response ) ) return false; $body = trim( wp_remote_retrieve_body( $response ) ); $body = json_decode( $body, true ); if ( ! is_array( $body ) || ! isset( $body['offers'] ) ) return false; $offers = $body['offers']; foreach ( $offers as &$offer ) { foreach ( $offer as $offer_key => $value ) { if ( 'packages' == $offer_key ) $offer['packages'] = (object) array_intersect_key( array_map( 'esc_url', $offer['packages'] ), array_fill_keys( array( 'full', 'no_content', 'new_bundled', 'partial', 'rollback' ), '' ) ); elseif ( 'download' == $offer_key ) $offer['download'] = esc_url( $value ); else $offer[ $offer_key ] = esc_html( $value ); } $offer = (object) array_intersect_key( $offer, array_fill_keys( array( 'response', 'download', 'locale', 'packages', 'current', 'version', 'php_version', 'mysql_version', 'new_bundled', 'partial_version', 'notify_email', 'support_email' ), '' ) ); } $updates = new stdClass(); $updates->updates = $offers; $updates->last_checked = time(); $updates->version_checked = $wp_version; if ( isset( $body['translations'] ) ) $updates->translations = $body['translations']; set_site_transient( 'update_core', $updates ); if ( ! empty( $body['ttl'] ) ) { $ttl = (int) $body['ttl']; if ( $ttl && ( time() + $ttl < wp_next_scheduled( 'wp_version_check' ) ) ) { // Queue an event to re-run the update check in $ttl seconds. wp_schedule_single_event( time() + $ttl, 'wp_version_check' ); } } // Trigger a background updates check if running non-interactively, and we weren't called from the update handler. if ( defined( 'DOING_CRON' ) && DOING_CRON && ! doing_action( 'wp_maybe_auto_update' ) ) { do_action( 'wp_maybe_auto_update' ); } } /** * Check plugin versions against the latest versions hosted on WordPress.org. * * The WordPress version, PHP version, and Locale is sent along with a list of * all plugins installed. Checks against the WordPress server at * api.wordpress.org. Will only check if WordPress isn't installing. * * @since 2.3.0 * @uses $wp_version Used to notify the WordPress version. * * @param array $extra_stats Extra statistics to report to the WordPress.org API. * @return mixed Returns null if update is unsupported. Returns false if check is too soon. */ function wp_update_plugins( $extra_stats = array() ) { include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version if ( defined('WP_INSTALLING') ) return false; // If running blog-side, bail unless we've not checked in the last 12 hours if ( !function_exists( 'get_plugins' ) ) require_once( ABSPATH . 'wp-admin/includes/plugin.php' ); $plugins = get_plugins(); $translations = wp_get_installed_translations( 'plugins' ); $active = get_option( 'active_plugins', array() ); $current = get_site_transient( 'update_plugins' ); if ( ! is_object($current) ) $current = new stdClass; $new_option = new stdClass; $new_option->last_checked = time(); // Check for update on a different schedule, depending on the page. switch ( current_filter() ) { case 'upgrader_process_complete' : $timeout = 0; break; case 'load-update-core.php' : $timeout = MINUTE_IN_SECONDS; break; case 'load-plugins.php' : case 'load-update.php' : $timeout = HOUR_IN_SECONDS; break; default : if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 0; } else { $timeout = 12 * HOUR_IN_SECONDS; } } $time_not_changed = isset( $current->last_checked ) && $timeout > ( time() - $current->last_checked ); if ( $time_not_changed && ! $extra_stats ) { $plugin_changed = false; foreach ( $plugins as $file => $p ) { $new_option->checked[ $file ] = $p['Version']; if ( !isset( $current->checked[ $file ] ) || strval($current->checked[ $file ]) !== strval($p['Version']) ) $plugin_changed = true; } if ( isset ( $current->response ) && is_array( $current->response ) ) { foreach ( $current->response as $plugin_file => $update_details ) { if ( ! isset($plugins[ $plugin_file ]) ) { $plugin_changed = true; break; } } } // Bail if we've checked recently and if nothing has changed if ( ! $plugin_changed ) return false; } // Update last_checked for current to prevent multiple blocking requests if request hangs $current->last_checked = time(); set_site_transient( 'update_plugins', $current ); $to_send = compact( 'plugins', 'active' ); $locales = array( get_locale() ); /** * Filter the locales requested for plugin translations. * * @since 3.7.0 * * @param array $locales Plugin locale. Default is current locale of the site. */ $locales = apply_filters( 'plugins_update_check_locales', $locales ); if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 30; } else { // Three seconds, plus one extra second for every 10 plugins $timeout = 3 + (int) ( count( $plugins ) / 10 ); } $options = array( 'timeout' => $timeout, 'body' => array( 'plugins' => json_encode( $to_send ), 'translations' => json_encode( $translations ), 'locale' => json_encode( $locales ), 'all' => json_encode( true ), ), 'user-agent' => 'WordPress/' . $wp_version . '; ' . get_bloginfo( 'url' ) ); if ( $extra_stats ) { $options['body']['update_stats'] = json_encode( $extra_stats ); } $url = $http_url = 'http://api.wordpress.org/plugins/update-check/1.1/'; if ( $ssl = wp_http_supports( array( 'ssl' ) ) ) $url = set_url_scheme( $url, 'https' ); $raw_response = wp_remote_post( $url, $options ); if ( $ssl && is_wp_error( $raw_response ) ) { trigger_error( __( 'An unexpected error occurred. Something may be wrong with WordPress.org or this server’s configuration. If you continue to have problems, please try the support forums.' ) . ' ' . __( '(WordPress could not establish a secure connection to WordPress.org. Please contact your server administrator.)' ), headers_sent() || WP_DEBUG ? E_USER_WARNING : E_USER_NOTICE ); $raw_response = wp_remote_post( $http_url, $options ); } if ( is_wp_error( $raw_response ) || 200 != wp_remote_retrieve_response_code( $raw_response ) ) return false; $response = json_decode( wp_remote_retrieve_body( $raw_response ), true ); foreach ( $response['plugins'] as &$plugin ) { $plugin = (object) $plugin; } unset( $plugin ); foreach ( $response['no_update'] as &$plugin ) { $plugin = (object) $plugin; } unset( $plugin ); if ( is_array( $response ) ) { $new_option->response = $response['plugins']; $new_option->translations = $response['translations']; // TODO: Perhaps better to store no_update in a separate transient with an expiry? $new_option->no_update = $response['no_update']; } else { $new_option->response = array(); $new_option->translations = array(); $new_option->no_update = array(); } set_site_transient( 'update_plugins', $new_option ); } /** * Check theme versions against the latest versions hosted on WordPress.org. * * A list of all themes installed in sent to WP. Checks against the * WordPress server at api.wordpress.org. Will only check if WordPress isn't * installing. * * @since 2.7.0 * @uses $wp_version Used to notify the WordPress version. * * @param array $extra_stats Extra statistics to report to the WordPress.org API. * @return mixed Returns null if update is unsupported. Returns false if check is too soon. */ function wp_update_themes( $extra_stats = array() ) { include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version if ( defined( 'WP_INSTALLING' ) ) return false; $installed_themes = wp_get_themes(); $translations = wp_get_installed_translations( 'themes' ); $last_update = get_site_transient( 'update_themes' ); if ( ! is_object($last_update) ) $last_update = new stdClass; $themes = $checked = $request = array(); // Put slug of current theme into request. $request['active'] = get_option( 'stylesheet' ); foreach ( $installed_themes as $theme ) { $checked[ $theme->get_stylesheet() ] = $theme->get('Version'); $themes[ $theme->get_stylesheet() ] = array( 'Name' => $theme->get('Name'), 'Title' => $theme->get('Name'), 'Version' => $theme->get('Version'), 'Author' => $theme->get('Author'), 'Author URI' => $theme->get('AuthorURI'), 'Template' => $theme->get_template(), 'Stylesheet' => $theme->get_stylesheet(), ); } // Check for update on a different schedule, depending on the page. switch ( current_filter() ) { case 'upgrader_process_complete' : $timeout = 0; break; case 'load-update-core.php' : $timeout = MINUTE_IN_SECONDS; break; case 'load-themes.php' : case 'load-update.php' : $timeout = HOUR_IN_SECONDS; break; default : if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 0; } else { $timeout = 12 * HOUR_IN_SECONDS; } } $time_not_changed = isset( $last_update->last_checked ) && $timeout > ( time() - $last_update->last_checked ); if ( $time_not_changed && ! $extra_stats ) { $theme_changed = false; foreach ( $checked as $slug => $v ) { if ( !isset( $last_update->checked[ $slug ] ) || strval($last_update->checked[ $slug ]) !== strval($v) ) $theme_changed = true; } if ( isset ( $last_update->response ) && is_array( $last_update->response ) ) { foreach ( $last_update->response as $slug => $update_details ) { if ( ! isset($checked[ $slug ]) ) { $theme_changed = true; break; } } } // Bail if we've checked recently and if nothing has changed if ( ! $theme_changed ) return false; } // Update last_checked for current to prevent multiple blocking requests if request hangs $last_update->last_checked = time(); set_site_transient( 'update_themes', $last_update ); $request['themes'] = $themes; $locales = array( get_locale() ); /** * Filter the locales requested for theme translations. * * @since 3.7.0 * * @param array $locales Theme locale. Default is current locale of the site. */ $locales = apply_filters( 'themes_update_check_locales', $locales ); if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 30; } else { // Three seconds, plus one extra second for every 10 themes $timeout = 3 + (int) ( count( $themes ) / 10 ); } $options = array( 'timeout' => $timeout, 'body' => array( 'themes' => json_encode( $request ), 'translations' => json_encode( $translations ), 'locale' => json_encode( $locales ), ), 'user-agent' => 'WordPress/' . $wp_version . '; ' . get_bloginfo( 'url' ) ); if ( $extra_stats ) { $options['body']['update_stats'] = json_encode( $extra_stats ); } $url = $http_url = 'http://api.wordpress.org/themes/update-check/1.1/'; if ( $ssl = wp_http_supports( array( 'ssl' ) ) ) $url = set_url_scheme( $url, 'https' ); $raw_response = wp_remote_post( $url, $options ); if ( $ssl && is_wp_error( $raw_response ) ) { trigger_error( __( 'An unexpected error occurred. Something may be wrong with WordPress.org or this server’s configuration. If you continue to have problems, please try the support forums.' ) . ' ' . __( '(WordPress could not establish a secure connection to WordPress.org. Please contact your server administrator.)' ), headers_sent() || WP_DEBUG ? E_USER_WARNING : E_USER_NOTICE ); $raw_response = wp_remote_post( $http_url, $options ); } if ( is_wp_error( $raw_response ) || 200 != wp_remote_retrieve_response_code( $raw_response ) ) return false; $new_update = new stdClass; $new_update->last_checked = time(); $new_update->checked = $checked; $response = json_decode( wp_remote_retrieve_body( $raw_response ), true ); if ( is_array( $response ) ) { $new_update->response = $response['themes']; $new_update->translations = $response['translations']; } set_site_transient( 'update_themes', $new_update ); } /** * Performs WordPress automatic background updates. * * @since 3.7.0 */ function wp_maybe_auto_update() { include_once( ABSPATH . '/wp-admin/includes/admin.php' ); include_once( ABSPATH . '/wp-admin/includes/class-wp-upgrader.php' ); $upgrader = new WP_Automatic_Updater; $upgrader->run(); } /** * Retrieves a list of all language updates available. * * @since 3.7.0 */ function wp_get_translation_updates() { $updates = array(); $transients = array( 'update_core' => 'core', 'update_plugins' => 'plugin', 'update_themes' => 'theme' ); foreach ( $transients as $transient => $type ) { $transient = get_site_transient( $transient ); if ( empty( $transient->translations ) ) continue; foreach ( $transient->translations as $translation ) { $updates[] = (object) $translation; } } return $updates; } /** * Collect counts and UI strings for available updates * * @since 3.3.0 * * @return array */ function wp_get_update_data() { $counts = array( 'plugins' => 0, 'themes' => 0, 'wordpress' => 0, 'translations' => 0 ); if ( $plugins = current_user_can( 'update_plugins' ) ) { $update_plugins = get_site_transient( 'update_plugins' ); if ( ! empty( $update_plugins->response ) ) $counts['plugins'] = count( $update_plugins->response ); } if ( $themes = current_user_can( 'update_themes' ) ) { $update_themes = get_site_transient( 'update_themes' ); if ( ! empty( $update_themes->response ) ) $counts['themes'] = count( $update_themes->response ); } if ( ( $core = current_user_can( 'update_core' ) ) && function_exists( 'get_core_updates' ) ) { $update_wordpress = get_core_updates( array('dismissed' => false) ); if ( ! empty( $update_wordpress ) && ! in_array( $update_wordpress[0]->response, array('development', 'latest') ) && current_user_can('update_core') ) $counts['wordpress'] = 1; } if ( ( $core || $plugins || $themes ) && wp_get_translation_updates() ) $counts['translations'] = 1; $counts['total'] = $counts['plugins'] + $counts['themes'] + $counts['wordpress'] + $counts['translations']; $titles = array(); if ( $counts['wordpress'] ) $titles['wordpress'] = sprintf( __( '%d WordPress Update'), $counts['wordpress'] ); if ( $counts['plugins'] ) $titles['plugins'] = sprintf( _n( '%d Plugin Update', '%d Plugin Updates', $counts['plugins'] ), $counts['plugins'] ); if ( $counts['themes'] ) $titles['themes'] = sprintf( _n( '%d Theme Update', '%d Theme Updates', $counts['themes'] ), $counts['themes'] ); if ( $counts['translations'] ) $titles['translations'] = __( 'Translation Updates' ); $update_title = $titles ? esc_attr( implode( ', ', $titles ) ) : ''; $update_data = array( 'counts' => $counts, 'title' => $update_title ); /** * Filter the returned array of update data for plugins, themes, and WordPress core. * * @since 3.5.0 * * @param array $update_data { * Fetched update data. * * @type array $counts An array of counts for available plugin, theme, and WordPress updates. * @type string $update_title Titles of available updates. * } * @param array $titles An array of update counts and UI strings for available updates. */ return apply_filters( 'wp_get_update_data', $update_data, $titles ); } function _maybe_update_core() { include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version $current = get_site_transient( 'update_core' ); if ( isset( $current->last_checked ) && 12 * HOUR_IN_SECONDS > ( time() - $current->last_checked ) && isset( $current->version_checked ) && $current->version_checked == $wp_version ) return; wp_version_check(); } /** * Check the last time plugins were run before checking plugin versions. * * This might have been backported to WordPress 2.6.1 for performance reasons. * This is used for the wp-admin to check only so often instead of every page * load. * * @since 2.7.0 * @access private */ function _maybe_update_plugins() { $current = get_site_transient( 'update_plugins' ); if ( isset( $current->last_checked ) && 12 * HOUR_IN_SECONDS > ( time() - $current->last_checked ) ) return; wp_update_plugins(); } /** * Check themes versions only after a duration of time. * * This is for performance reasons to make sure that on the theme version * checker is not run on every page load. * * @since 2.7.0 * @access private */ function _maybe_update_themes() { $current = get_site_transient( 'update_themes' ); if ( isset( $current->last_checked ) && 12 * HOUR_IN_SECONDS > ( time() - $current->last_checked ) ) return; wp_update_themes(); } /** * Schedule core, theme, and plugin update checks. * * @since 3.1.0 */ function wp_schedule_update_checks() { if ( !wp_next_scheduled('wp_version_check') && !defined('WP_INSTALLING') ) wp_schedule_event(time(), 'twicedaily', 'wp_version_check'); if ( !wp_next_scheduled('wp_update_plugins') && !defined('WP_INSTALLING') ) wp_schedule_event(time(), 'twicedaily', 'wp_update_plugins'); if ( !wp_next_scheduled('wp_update_themes') && !defined('WP_INSTALLING') ) wp_schedule_event(time(), 'twicedaily', 'wp_update_themes'); if ( ( wp_next_scheduled( 'wp_maybe_auto_update' ) > ( time() + HOUR_IN_SECONDS ) ) && ! defined('WP_INSTALLING') ) wp_clear_scheduled_hook( 'wp_maybe_auto_update' ); } if ( ( ! is_main_site() && ! is_network_admin() ) || ( defined( 'DOING_AJAX' ) && DOING_AJAX ) ) return; add_action( 'admin_init', '_maybe_update_core' ); add_action( 'wp_version_check', 'wp_version_check' ); add_action( 'upgrader_process_complete', 'wp_version_check', 10, 0 ); add_action( 'load-plugins.php', 'wp_update_plugins' ); add_action( 'load-update.php', 'wp_update_plugins' ); add_action( 'load-update-core.php', 'wp_update_plugins' ); add_action( 'admin_init', '_maybe_update_plugins' ); add_action( 'wp_update_plugins', 'wp_update_plugins' ); add_action( 'upgrader_process_complete', 'wp_update_plugins', 10, 0 ); add_action( 'load-themes.php', 'wp_update_themes' ); add_action( 'load-update.php', 'wp_update_themes' ); add_action( 'load-update-core.php', 'wp_update_themes' ); add_action( 'admin_init', '_maybe_update_themes' ); add_action( 'wp_update_themes', 'wp_update_themes' ); add_action( 'upgrader_process_complete', 'wp_update_themes', 10, 0 ); add_action( 'wp_maybe_auto_update', 'wp_maybe_auto_update' ); add_action('init', 'wp_schedule_update_checks'); Europa prepara la defensa frente a las superbacteriasSesiónDeControl.com
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Contra las superbacterias


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Este artículo ha sido escrito en Materia, web de noticias de ciencia, tecnología, salud y medio ambiente, que comparte su contenido para ser republicado.


Escrito el 1 de agosto de 2013 a las 13:55 | Clasificado en Ciencia

La Unión Europea anuncia un proyecto de 4,1 millones de euros para luchar contra bacterias resistentes a los antibióticos

Las unidades de cuidados intensivos son un lugar especialmente amenazado por las superbacterias (Foto: Calleamanecer)
Las unidades de cuidados intensivos son un lugar especialmente amenazado por las superbacterias (Foto: Calleamanecer)

Hace poco más de medio siglo los humanos empezaron a conseguir grandes victorias contra las bacterias. Desde el principio de los tiempos, infecciones que ahora resultan insignificantes podían complicarse y acabar con la vida de una persona. Eso cambió con la introducción de los antibióticos. Sin embargo, después de décadas de uso, las bacterias han aprendido a resistir a las armas humanas, intercambiando genes que les hacen cada vez más inmunes a los fármacos y ayudadas por el mal uso que se hace de los antibióticos. Cada vez que no se acaba un tratamiento completo con estos medicamentos o se utilizan antibióticos sin control para tratar animales, se facilita la adaptación de los patógenos a los fármacos y se pierde una batalla en la que las bacterias están ganando cada vez más terreno. La semana pasada,un informe del Centro Europeo de Control de las Enfermedades (ECDC) afirmaba que las infecciones con bacterias resistentes a los antibióticos de último recurso están creciendo en España, y otro estudio reciente apuntaba que los españoles tienen muchos más genes de resistencia a antibióticos que los daneses o los estadounidenses.

En esa carrera armamentística, sin embargo, los humanos también cuentan con sus bazas. La semana pasada se anunció que la Unión Europea dedicará 4,1 millones de euros a un proyecto de tres años que empezará este verano y buscará nuevos fármacos para combatir a bacterias multirresistentes. El consorcio NABARSI reunirá a tres equipos de investigación y dos empresas para buscar nuevos compuestos con los que hacer frente a bacterias con técnicas que combinarán la química, la biología y la computación.

En este proyecto, la empresa Omnia Molecular, surgida del Instituto de Investigacion Biomédica de Barcelona, realizará un papel fundamental. Los equipos de investigación del consorcio propondrán moléculas seleccionadas por sistemas bioinformáticos con potencial para combatir algunas de las bacterias del grupo ESKAPE, versiones especialmente resistentes de seis especies de microorganismos (Enterococcus faecium, Staphylococcus aureus, Klebsiellaspecies, Acinetobacter baumannii, Pseudomonas aeruginosa, andEnterobacter). Omnia pondrá a prueba las posibilidades de éxito de esas moléculas con un sistema de filtrado patentado por esta compañía.

En este mecanismo de cribado, según explica Lluis Ribas, fundador de Omnia, “se toma la diana terapéutica, que puede ser una bacteria o un hongo, y se inserta en una célula humana”. Después se prueba el fármaco con las células que tienen la diana en su interior y se observa cuáles son capaces de inhibir la enfermedad sin dañar al mismo tiempo a la célula. “El filtro es muy duro y hay muy pocas moléculas que pasen el filtro”, explica Ribas. Sin embargo, gracias a esa dureza en la selección, las moléculas que pasan tienen más probabilidades de éxito en las etapas posteriores ahorrando así esfuerzo y recursos en los ensayos con modelos animales y después con humanos.

Cientos de miles de muertes al año

El principal problema de las bacterias multirresistentes se presenta en las unidades de cuidados intensivos. En estos entornos, y en particular con pacientes que tienen el sistema inmune débil, es donde suponen un mayor peligro las superbacterias. Sin embargo, según explica Ribas, también hay ocasiones, como en el de las conocidas como bacterias comecarne, en el que estas infecciones afectan a personas perfectamente sanas. Aunque es difícil calcular el número de muertes causadas por todos estos patógenos adaptados a los antibióticos, la Organización Mundial de la Salud calcula que solo la versión resistente de la tuberculosis provoca 150.000 muertes al año.

El sistema de filtro que ayudará a seleccionar las nuevas armas para luchar contra esta amenaza se comenzó a utilizar en 2008 y también puede tener utilidad para el desarrollo de herbicidas e insecticidas. Pese a lo prometedor del sistema, la situación económica “ha afectado de lleno” a Omnia. “Si no fuese por los fondos europeos, la empresa no tendría continuidad, porque en estos momentos es muy difícil, por no decir imposible, conseguir financiación para empresas en este punto de desarrollo, ni local ni internacionalmente”, lamenta Ribas. “El problema —continúa— es que el riesgo que se percibe es un riesgo geográfico y lo más frecuente es que el proyecto tecnológico no se llegue a evaluar”.  Ese riesgo geográfico asociado a estar situados en un país en problemas como España ha hecho que Ribas se haya planteado llevar Omnia a otro país, aunque reconoce que tampoco es una opción sencilla.

Fuente: Europa prepara la defensa frente a las superbacterias

Autor: Daniel Mediavilla

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