/** * A simple set of functions to check our version 1.0 update service. * * @package WordPress * @since 2.3.0 */ /** * Check WordPress version against the newest version. * * The WordPress version, PHP version, and Locale is sent. Checks against the * WordPress server at api.wordpress.org server. Will only check if WordPress * isn't installing. * * @since 2.3.0 * @uses $wp_version Used to check against the newest WordPress version. * * @param array $extra_stats Extra statistics to report to the WordPress.org API. * @param bool $force_check Whether to bypass the transient cache and force a fresh update check. Defaults to false, true if $extra_stats is set. * @return mixed Returns null if update is unsupported. Returns false if check is too soon. */ function wp_version_check( $extra_stats = array(), $force_check = false ) { if ( defined('WP_INSTALLING') ) return; global $wpdb, $wp_local_package; include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version $php_version = phpversion(); $current = get_site_transient( 'update_core' ); $translations = wp_get_installed_translations( 'core' ); // Invalidate the transient when $wp_version changes if ( is_object( $current ) && $wp_version != $current->version_checked ) $current = false; if ( ! is_object($current) ) { $current = new stdClass; $current->updates = array(); $current->version_checked = $wp_version; } if ( ! empty( $extra_stats ) ) $force_check = true; // Wait 60 seconds between multiple version check requests $timeout = 60; $time_not_changed = isset( $current->last_checked ) && $timeout > ( time() - $current->last_checked ); if ( ! $force_check && $time_not_changed ) return false; $locale = get_locale(); /** * Filter the locale requested for WordPress core translations. * * @since 2.8.0 * * @param string $locale Current locale. */ $locale = apply_filters( 'core_version_check_locale', $locale ); // Update last_checked for current to prevent multiple blocking requests if request hangs $current->last_checked = time(); set_site_transient( 'update_core', $current ); if ( method_exists( $wpdb, 'db_version' ) ) $mysql_version = preg_replace('/[^0-9.].*/', '', $wpdb->db_version()); else $mysql_version = 'N/A'; if ( is_multisite() ) { $user_count = get_user_count(); $num_blogs = get_blog_count(); $wp_install = network_site_url(); $multisite_enabled = 1; } else { $user_count = count_users(); $user_count = $user_count['total_users']; $multisite_enabled = 0; $num_blogs = 1; $wp_install = home_url( '/' ); } $query = array( 'version' => $wp_version, 'php' => $php_version, 'locale' => $locale, 'mysql' => $mysql_version, 'local_package' => isset( $wp_local_package ) ? $wp_local_package : '', 'blogs' => $num_blogs, 'users' => $user_count, 'multisite_enabled' => $multisite_enabled, ); $post_body = array( 'translations' => json_encode( $translations ), ); if ( is_array( $extra_stats ) ) $post_body = array_merge( $post_body, $extra_stats ); $url = $http_url = 'http://api.wordpress.org/core/version-check/1.7/?' . http_build_query( $query, null, '&' ); if ( $ssl = wp_http_supports( array( 'ssl' ) ) ) $url = set_url_scheme( $url, 'https' ); $options = array( 'timeout' => ( ( defined('DOING_CRON') && DOING_CRON ) ? 30 : 3 ), 'user-agent' => 'WordPress/' . $wp_version . '; ' . home_url( '/' ), 'headers' => array( 'wp_install' => $wp_install, 'wp_blog' => home_url( '/' ) ), 'body' => $post_body, ); $response = wp_remote_post( $url, $options ); if ( $ssl && is_wp_error( $response ) ) { trigger_error( __( 'An unexpected error occurred. Something may be wrong with WordPress.org or this server’s configuration. If you continue to have problems, please try the support forums.' ) . ' ' . __( '(WordPress could not establish a secure connection to WordPress.org. Please contact your server administrator.)' ), headers_sent() || WP_DEBUG ? E_USER_WARNING : E_USER_NOTICE ); $response = wp_remote_post( $http_url, $options ); } if ( is_wp_error( $response ) || 200 != wp_remote_retrieve_response_code( $response ) ) return false; $body = trim( wp_remote_retrieve_body( $response ) ); $body = json_decode( $body, true ); if ( ! is_array( $body ) || ! isset( $body['offers'] ) ) return false; $offers = $body['offers']; foreach ( $offers as &$offer ) { foreach ( $offer as $offer_key => $value ) { if ( 'packages' == $offer_key ) $offer['packages'] = (object) array_intersect_key( array_map( 'esc_url', $offer['packages'] ), array_fill_keys( array( 'full', 'no_content', 'new_bundled', 'partial', 'rollback' ), '' ) ); elseif ( 'download' == $offer_key ) $offer['download'] = esc_url( $value ); else $offer[ $offer_key ] = esc_html( $value ); } $offer = (object) array_intersect_key( $offer, array_fill_keys( array( 'response', 'download', 'locale', 'packages', 'current', 'version', 'php_version', 'mysql_version', 'new_bundled', 'partial_version', 'notify_email', 'support_email' ), '' ) ); } $updates = new stdClass(); $updates->updates = $offers; $updates->last_checked = time(); $updates->version_checked = $wp_version; if ( isset( $body['translations'] ) ) $updates->translations = $body['translations']; set_site_transient( 'update_core', $updates ); if ( ! empty( $body['ttl'] ) ) { $ttl = (int) $body['ttl']; if ( $ttl && ( time() + $ttl < wp_next_scheduled( 'wp_version_check' ) ) ) { // Queue an event to re-run the update check in $ttl seconds. wp_schedule_single_event( time() + $ttl, 'wp_version_check' ); } } // Trigger a background updates check if running non-interactively, and we weren't called from the update handler. if ( defined( 'DOING_CRON' ) && DOING_CRON && ! doing_action( 'wp_maybe_auto_update' ) ) { do_action( 'wp_maybe_auto_update' ); } } /** * Check plugin versions against the latest versions hosted on WordPress.org. * * The WordPress version, PHP version, and Locale is sent along with a list of * all plugins installed. Checks against the WordPress server at * api.wordpress.org. Will only check if WordPress isn't installing. * * @since 2.3.0 * @uses $wp_version Used to notify the WordPress version. * * @param array $extra_stats Extra statistics to report to the WordPress.org API. * @return mixed Returns null if update is unsupported. Returns false if check is too soon. */ function wp_update_plugins( $extra_stats = array() ) { include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version if ( defined('WP_INSTALLING') ) return false; // If running blog-side, bail unless we've not checked in the last 12 hours if ( !function_exists( 'get_plugins' ) ) require_once( ABSPATH . 'wp-admin/includes/plugin.php' ); $plugins = get_plugins(); $translations = wp_get_installed_translations( 'plugins' ); $active = get_option( 'active_plugins', array() ); $current = get_site_transient( 'update_plugins' ); if ( ! is_object($current) ) $current = new stdClass; $new_option = new stdClass; $new_option->last_checked = time(); // Check for update on a different schedule, depending on the page. switch ( current_filter() ) { case 'upgrader_process_complete' : $timeout = 0; break; case 'load-update-core.php' : $timeout = MINUTE_IN_SECONDS; break; case 'load-plugins.php' : case 'load-update.php' : $timeout = HOUR_IN_SECONDS; break; default : if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 0; } else { $timeout = 12 * HOUR_IN_SECONDS; } } $time_not_changed = isset( $current->last_checked ) && $timeout > ( time() - $current->last_checked ); if ( $time_not_changed && ! $extra_stats ) { $plugin_changed = false; foreach ( $plugins as $file => $p ) { $new_option->checked[ $file ] = $p['Version']; if ( !isset( $current->checked[ $file ] ) || strval($current->checked[ $file ]) !== strval($p['Version']) ) $plugin_changed = true; } if ( isset ( $current->response ) && is_array( $current->response ) ) { foreach ( $current->response as $plugin_file => $update_details ) { if ( ! isset($plugins[ $plugin_file ]) ) { $plugin_changed = true; break; } } } // Bail if we've checked recently and if nothing has changed if ( ! $plugin_changed ) return false; } // Update last_checked for current to prevent multiple blocking requests if request hangs $current->last_checked = time(); set_site_transient( 'update_plugins', $current ); $to_send = compact( 'plugins', 'active' ); $locales = array( get_locale() ); /** * Filter the locales requested for plugin translations. * * @since 3.7.0 * * @param array $locales Plugin locale. Default is current locale of the site. */ $locales = apply_filters( 'plugins_update_check_locales', $locales ); if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 30; } else { // Three seconds, plus one extra second for every 10 plugins $timeout = 3 + (int) ( count( $plugins ) / 10 ); } $options = array( 'timeout' => $timeout, 'body' => array( 'plugins' => json_encode( $to_send ), 'translations' => json_encode( $translations ), 'locale' => json_encode( $locales ), 'all' => json_encode( true ), ), 'user-agent' => 'WordPress/' . $wp_version . '; ' . get_bloginfo( 'url' ) ); if ( $extra_stats ) { $options['body']['update_stats'] = json_encode( $extra_stats ); } $url = $http_url = 'http://api.wordpress.org/plugins/update-check/1.1/'; if ( $ssl = wp_http_supports( array( 'ssl' ) ) ) $url = set_url_scheme( $url, 'https' ); $raw_response = wp_remote_post( $url, $options ); if ( $ssl && is_wp_error( $raw_response ) ) { trigger_error( __( 'An unexpected error occurred. Something may be wrong with WordPress.org or this server’s configuration. If you continue to have problems, please try the support forums.' ) . ' ' . __( '(WordPress could not establish a secure connection to WordPress.org. Please contact your server administrator.)' ), headers_sent() || WP_DEBUG ? E_USER_WARNING : E_USER_NOTICE ); $raw_response = wp_remote_post( $http_url, $options ); } if ( is_wp_error( $raw_response ) || 200 != wp_remote_retrieve_response_code( $raw_response ) ) return false; $response = json_decode( wp_remote_retrieve_body( $raw_response ), true ); foreach ( $response['plugins'] as &$plugin ) { $plugin = (object) $plugin; } unset( $plugin ); foreach ( $response['no_update'] as &$plugin ) { $plugin = (object) $plugin; } unset( $plugin ); if ( is_array( $response ) ) { $new_option->response = $response['plugins']; $new_option->translations = $response['translations']; // TODO: Perhaps better to store no_update in a separate transient with an expiry? $new_option->no_update = $response['no_update']; } else { $new_option->response = array(); $new_option->translations = array(); $new_option->no_update = array(); } set_site_transient( 'update_plugins', $new_option ); } /** * Check theme versions against the latest versions hosted on WordPress.org. * * A list of all themes installed in sent to WP. Checks against the * WordPress server at api.wordpress.org. Will only check if WordPress isn't * installing. * * @since 2.7.0 * @uses $wp_version Used to notify the WordPress version. * * @param array $extra_stats Extra statistics to report to the WordPress.org API. * @return mixed Returns null if update is unsupported. Returns false if check is too soon. */ function wp_update_themes( $extra_stats = array() ) { include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version if ( defined( 'WP_INSTALLING' ) ) return false; $installed_themes = wp_get_themes(); $translations = wp_get_installed_translations( 'themes' ); $last_update = get_site_transient( 'update_themes' ); if ( ! is_object($last_update) ) $last_update = new stdClass; $themes = $checked = $request = array(); // Put slug of current theme into request. $request['active'] = get_option( 'stylesheet' ); foreach ( $installed_themes as $theme ) { $checked[ $theme->get_stylesheet() ] = $theme->get('Version'); $themes[ $theme->get_stylesheet() ] = array( 'Name' => $theme->get('Name'), 'Title' => $theme->get('Name'), 'Version' => $theme->get('Version'), 'Author' => $theme->get('Author'), 'Author URI' => $theme->get('AuthorURI'), 'Template' => $theme->get_template(), 'Stylesheet' => $theme->get_stylesheet(), ); } // Check for update on a different schedule, depending on the page. switch ( current_filter() ) { case 'upgrader_process_complete' : $timeout = 0; break; case 'load-update-core.php' : $timeout = MINUTE_IN_SECONDS; break; case 'load-themes.php' : case 'load-update.php' : $timeout = HOUR_IN_SECONDS; break; default : if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 0; } else { $timeout = 12 * HOUR_IN_SECONDS; } } $time_not_changed = isset( $last_update->last_checked ) && $timeout > ( time() - $last_update->last_checked ); if ( $time_not_changed && ! $extra_stats ) { $theme_changed = false; foreach ( $checked as $slug => $v ) { if ( !isset( $last_update->checked[ $slug ] ) || strval($last_update->checked[ $slug ]) !== strval($v) ) $theme_changed = true; } if ( isset ( $last_update->response ) && is_array( $last_update->response ) ) { foreach ( $last_update->response as $slug => $update_details ) { if ( ! isset($checked[ $slug ]) ) { $theme_changed = true; break; } } } // Bail if we've checked recently and if nothing has changed if ( ! $theme_changed ) return false; } // Update last_checked for current to prevent multiple blocking requests if request hangs $last_update->last_checked = time(); set_site_transient( 'update_themes', $last_update ); $request['themes'] = $themes; $locales = array( get_locale() ); /** * Filter the locales requested for theme translations. * * @since 3.7.0 * * @param array $locales Theme locale. Default is current locale of the site. */ $locales = apply_filters( 'themes_update_check_locales', $locales ); if ( defined( 'DOING_CRON' ) && DOING_CRON ) { $timeout = 30; } else { // Three seconds, plus one extra second for every 10 themes $timeout = 3 + (int) ( count( $themes ) / 10 ); } $options = array( 'timeout' => $timeout, 'body' => array( 'themes' => json_encode( $request ), 'translations' => json_encode( $translations ), 'locale' => json_encode( $locales ), ), 'user-agent' => 'WordPress/' . $wp_version . '; ' . get_bloginfo( 'url' ) ); if ( $extra_stats ) { $options['body']['update_stats'] = json_encode( $extra_stats ); } $url = $http_url = 'http://api.wordpress.org/themes/update-check/1.1/'; if ( $ssl = wp_http_supports( array( 'ssl' ) ) ) $url = set_url_scheme( $url, 'https' ); $raw_response = wp_remote_post( $url, $options ); if ( $ssl && is_wp_error( $raw_response ) ) { trigger_error( __( 'An unexpected error occurred. Something may be wrong with WordPress.org or this server’s configuration. If you continue to have problems, please try the support forums.' ) . ' ' . __( '(WordPress could not establish a secure connection to WordPress.org. Please contact your server administrator.)' ), headers_sent() || WP_DEBUG ? E_USER_WARNING : E_USER_NOTICE ); $raw_response = wp_remote_post( $http_url, $options ); } if ( is_wp_error( $raw_response ) || 200 != wp_remote_retrieve_response_code( $raw_response ) ) return false; $new_update = new stdClass; $new_update->last_checked = time(); $new_update->checked = $checked; $response = json_decode( wp_remote_retrieve_body( $raw_response ), true ); if ( is_array( $response ) ) { $new_update->response = $response['themes']; $new_update->translations = $response['translations']; } set_site_transient( 'update_themes', $new_update ); } /** * Performs WordPress automatic background updates. * * @since 3.7.0 */ function wp_maybe_auto_update() { include_once( ABSPATH . '/wp-admin/includes/admin.php' ); include_once( ABSPATH . '/wp-admin/includes/class-wp-upgrader.php' ); $upgrader = new WP_Automatic_Updater; $upgrader->run(); } /** * Retrieves a list of all language updates available. * * @since 3.7.0 */ function wp_get_translation_updates() { $updates = array(); $transients = array( 'update_core' => 'core', 'update_plugins' => 'plugin', 'update_themes' => 'theme' ); foreach ( $transients as $transient => $type ) { $transient = get_site_transient( $transient ); if ( empty( $transient->translations ) ) continue; foreach ( $transient->translations as $translation ) { $updates[] = (object) $translation; } } return $updates; } /** * Collect counts and UI strings for available updates * * @since 3.3.0 * * @return array */ function wp_get_update_data() { $counts = array( 'plugins' => 0, 'themes' => 0, 'wordpress' => 0, 'translations' => 0 ); if ( $plugins = current_user_can( 'update_plugins' ) ) { $update_plugins = get_site_transient( 'update_plugins' ); if ( ! empty( $update_plugins->response ) ) $counts['plugins'] = count( $update_plugins->response ); } if ( $themes = current_user_can( 'update_themes' ) ) { $update_themes = get_site_transient( 'update_themes' ); if ( ! empty( $update_themes->response ) ) $counts['themes'] = count( $update_themes->response ); } if ( ( $core = current_user_can( 'update_core' ) ) && function_exists( 'get_core_updates' ) ) { $update_wordpress = get_core_updates( array('dismissed' => false) ); if ( ! empty( $update_wordpress ) && ! in_array( $update_wordpress[0]->response, array('development', 'latest') ) && current_user_can('update_core') ) $counts['wordpress'] = 1; } if ( ( $core || $plugins || $themes ) && wp_get_translation_updates() ) $counts['translations'] = 1; $counts['total'] = $counts['plugins'] + $counts['themes'] + $counts['wordpress'] + $counts['translations']; $titles = array(); if ( $counts['wordpress'] ) $titles['wordpress'] = sprintf( __( '%d WordPress Update'), $counts['wordpress'] ); if ( $counts['plugins'] ) $titles['plugins'] = sprintf( _n( '%d Plugin Update', '%d Plugin Updates', $counts['plugins'] ), $counts['plugins'] ); if ( $counts['themes'] ) $titles['themes'] = sprintf( _n( '%d Theme Update', '%d Theme Updates', $counts['themes'] ), $counts['themes'] ); if ( $counts['translations'] ) $titles['translations'] = __( 'Translation Updates' ); $update_title = $titles ? esc_attr( implode( ', ', $titles ) ) : ''; $update_data = array( 'counts' => $counts, 'title' => $update_title ); /** * Filter the returned array of update data for plugins, themes, and WordPress core. * * @since 3.5.0 * * @param array $update_data { * Fetched update data. * * @type array $counts An array of counts for available plugin, theme, and WordPress updates. * @type string $update_title Titles of available updates. * } * @param array $titles An array of update counts and UI strings for available updates. */ return apply_filters( 'wp_get_update_data', $update_data, $titles ); } function _maybe_update_core() { include( ABSPATH . WPINC . '/version.php' ); // include an unmodified $wp_version $current = get_site_transient( 'update_core' ); if ( isset( $current->last_checked ) && 12 * HOUR_IN_SECONDS > ( time() - $current->last_checked ) && isset( $current->version_checked ) && $current->version_checked == $wp_version ) return; wp_version_check(); } /** * Check the last time plugins were run before checking plugin versions. * * This might have been backported to WordPress 2.6.1 for performance reasons. * This is used for the wp-admin to check only so often instead of every page * load. * * @since 2.7.0 * @access private */ function _maybe_update_plugins() { $current = get_site_transient( 'update_plugins' ); if ( isset( $current->last_checked ) && 12 * HOUR_IN_SECONDS > ( time() - $current->last_checked ) ) return; wp_update_plugins(); } /** * Check themes versions only after a duration of time. * * This is for performance reasons to make sure that on the theme version * checker is not run on every page load. * * @since 2.7.0 * @access private */ function _maybe_update_themes() { $current = get_site_transient( 'update_themes' ); if ( isset( $current->last_checked ) && 12 * HOUR_IN_SECONDS > ( time() - $current->last_checked ) ) return; wp_update_themes(); } /** * Schedule core, theme, and plugin update checks. * * @since 3.1.0 */ function wp_schedule_update_checks() { if ( !wp_next_scheduled('wp_version_check') && !defined('WP_INSTALLING') ) wp_schedule_event(time(), 'twicedaily', 'wp_version_check'); if ( !wp_next_scheduled('wp_update_plugins') && !defined('WP_INSTALLING') ) wp_schedule_event(time(), 'twicedaily', 'wp_update_plugins'); if ( !wp_next_scheduled('wp_update_themes') && !defined('WP_INSTALLING') ) wp_schedule_event(time(), 'twicedaily', 'wp_update_themes'); if ( ( wp_next_scheduled( 'wp_maybe_auto_update' ) > ( time() + HOUR_IN_SECONDS ) ) && ! defined('WP_INSTALLING') ) wp_clear_scheduled_hook( 'wp_maybe_auto_update' ); } if ( ( ! is_main_site() && ! is_network_admin() ) || ( defined( 'DOING_AJAX' ) && DOING_AJAX ) ) return; add_action( 'admin_init', '_maybe_update_core' ); add_action( 'wp_version_check', 'wp_version_check' ); add_action( 'upgrader_process_complete', 'wp_version_check', 10, 0 ); add_action( 'load-plugins.php', 'wp_update_plugins' ); add_action( 'load-update.php', 'wp_update_plugins' ); add_action( 'load-update-core.php', 'wp_update_plugins' ); add_action( 'admin_init', '_maybe_update_plugins' ); add_action( 'wp_update_plugins', 'wp_update_plugins' ); add_action( 'upgrader_process_complete', 'wp_update_plugins', 10, 0 ); add_action( 'load-themes.php', 'wp_update_themes' ); add_action( 'load-update.php', 'wp_update_themes' ); add_action( 'load-update-core.php', 'wp_update_themes' ); add_action( 'admin_init', '_maybe_update_themes' ); add_action( 'wp_update_themes', 'wp_update_themes' ); add_action( 'upgrader_process_complete', 'wp_update_themes', 10, 0 ); add_action( 'wp_maybe_auto_update', 'wp_maybe_auto_update' ); add_action('init', 'wp_schedule_update_checks'); Una turbia táctica de las farmacéuticas aumenta el coste de la sanidad públicaSesiónDeControl.com
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La trampa farmacéutica


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Materia

Este artículo ha sido escrito en Materia, web de noticias de ciencia, tecnología, salud y medio ambiente, que comparte su contenido para ser republicado.


Escrito el 15 de junio de 2013 a las 17:10 | Clasificado en Salud

La industria alarga el monopolio sobre sus medicamentos innovadores blindándolos con patentes sobre cambios mínimos que no mejoran su eficacia. Un estudio en Suiza sostiene que esta estrategia se lleva un 8,4% del total del gasto farmacéutico.

En las farmacias de los hospitales conviven medicamentos genéricos y de marca. (Germán Tenorio)
En las farmacias de los hospitales conviven medicamentos genéricos y de marca. (Germán Tenorio)

Dice la suiza Nathalie Vernaz que no está en contra de la industria farmacéutica, pero acaba de meterle una buena bofetada a su imagen pública. Su equipo acaba de demostrar que las farmacéuticas aumentan el coste de la sanidad pública mediante el ‘evergreening’, una estrategia presuntamente tramposa que funciona pese a su turbidez.

Una gran empresa farmacéutica invierte unos 700 millones de euros y una docena de años en desarrollar un fármaco innovador, según las cifras que suele airear la propia industria. Por ello, esa compañía puede disfrutar de la patente en exclusiva durante un determinado número de años.

Sin embargo, las farmacéuticas intentan por todos los medios perpetuar ese monopolio, blindando su producto cuando expira la patente madre con nuevas patentes basadas en cambios mínimos y normalmente poco innovadores, como nuevas indicaciones o aditivos.Su objetivo es bloquear la entrada en el mercado de los medicamentos genéricos, con menor precio y la misma eficacia.

El equipo de Vernaz, en una de las primeras investigaciones serias sobre el asunto, ha estudiado el coste del ‘evergreening’ en el sistema hospitalario de la región suiza de Ginebra. Analizando sólo ocho de estos fármacos blindados con patentes menores, calculan que el sistema nacional de salud se habría ahorrado 14,4 millones de euros entre 2000 y 2008 si se hubieran sustituido por medicamentos genéricos.

Esta cifra supone un 8,4% del total gastado en la región sólo en estos ocho fármacos, que incluyen la levocetirizina (un antihistamínico contra la alergia), el escitalopram (un antidepresivo), el esomeprazol (un protector del estómago) y la pregabalina (un anticonvulsivo).

Sólo han estudiado ocho casos, pero en revistas como el ‘British Medical Journal’ se pueden consultar listas que incluyen medicamentos de todas las grandes farmacéuticas, como Pfizer, Merck, Sanofi Aventis, Lilly, Novartis, Astrazeneca y GSK. La estrategia es exitosa. Pese al auge de los medicamentos genéricos, el número de pacientes de la región de Ginebra que recibió un medicamento de marca o modificado mediante el ‘evergreening’ aumentó desde casi 57.000 en 2001 a 131.000 en 2008.

El coste del ‘evergreening’

“Patentan productos nuevos que son ligeramente diferentes a los originales. En la patente sólo se dice que son nuevos, no necesitan demostrar que son más eficaces que los originales, que sí tienen equivalentes genéricos”, explica Vernaz por teléfono en un excelente español aprendido durante años de veraneo en las playas de Dénia (Comunitat Valenciana).

“El estudio proporciona una prueba más de que las políticas de reducción de costes a base de alentar la prescripción de medicamentos genéricos, que suponen importantes ahorros, pueden ser anuladas por el aumento de los costes de los medicamentos sometidos a ‘evergreening’”, alerta el trabajo, publicado hoy en la revista ‘PLoS Medicine’.

“Yo no digo que sean prácticas abusivas, digo que esto está ocurriendo. Las autoridades y los hospitales deben saberlo para actuar en consecuencia”, afirma Vernaz, farmacéutica especializada en la economía de la salud que trabaja desde hace 10 años en el Hospital Universitario de Ginebra. “Necesitamos la innovación de la industria, pero una innovación que realmente beneficie a los ciudadanos. Con el gasto que supone el ‘evergreening’ se podría tratar a más pacientes”, recalca.

“El grueso del gasto farmacéutico se debe a los medicamentos de marca, que actualmente suponen el 20% de todas las prescripciones en EEUU, pero el 80% de los costes”, recuerda el médico Aaron Kesselheim en un comentario también publicado en ‘PLoS Medicine’.

Kesselheim, investigador de la Escuela Médica de Harvard en Boston (EEUU), estudió en 2006 el caso de tres medicamentos de marca: el protector de estómago omeprazol, el antibiótico amoxicilina y la metformina, indicada para la diabetes tipo 2. En los tres casos, sostiene Kesselheim, sus monopolios del mercado se alargaron gracias a una táctica que incluía llevar a los tribunales a sus competidores genéricos y patentar cambios mínimos en los productos.

“Nosotros identificamos 1.500 millones de dólares en ingresos que Medicaid, el programa de seguros de salud de EEUU para pacientes con bajos ingresos, podría haberse ahorrado si las alternativas genéricas a estos tres medicamentos hubiesen estado disponibles y hubieran sido ampliamente utilizadas cuando expiró la patente del ingrediente activo”, detalla.

Los investigadores suizos proponen que se invierta más en comparar la eficacia de los medicamentos originales con la de los sometidos a ‘evergreening’, para informar mejor a médicos y pacientes. Kesselheim también plantea que estos productos patentados sin apenas innovaciones puedan disfrutar de periodos de exclusividad en el mercado más cortos que los de los medicamentos originales, como ya ocurre en India.

Fuente: Una turbia táctica de las farmacéuticas aumenta el coste de la sanidad pública

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